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In explaining its decision, the agency flagged concerns about complexities with regard to peptide-related impurities and active pharmaceutical ingredient (API) characterization, the potential for aggregation and a lack of human safety data
Mechanistically, BPC-157 promotes fibroblast activity, modulates the nitric oxide system, enhances angiogenesis through vascular-endothelial growth factor, downregulates proinflammatory cytokines, and stimulates collagen remodeling (Figure 1)
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